abstract：:Over the past three years, most efforts of virologists and immunologists involved in the field of Human Immunodeficiency Virus (HIV) have been focussed on strategies aimed at eradicating the infection. So far, however, all the approaches have been unsuccessful. Indeed, even if the currently available potent antiretrov...

journal_title：Journal of biological regulators and homeostatic agents

authors： Vella S,Palmisano L

更新日期：2000-01-01 00:00:00

abstract：:HAART is the cornerstone of HIV therapy, and has significantly reduced morbidity and mortality associated with HIV disease. The institution of HAART during the primary HIV-1 infection has a more profound influence on the ultimate pattern and rate of disease progression than therapy commenced later on. However, it also...

journal_title：Journal of biological regulators and homeostatic agents

authors： Rizzardi GP,Vaccarezza M,Capiluppi B,Tambussi G,Lazzarin A,Pantaleo G

更新日期：2000-01-01 00:00:00

abstract：:The primary objective of antiretroviral therapy is to suppress viral replication as soon as possible, as much as possible and for as long as possible, a concept so clearly emphasized by David Ho in 1995: "Treat HIV early and hard!". That, however, seems an ideal objective by a number of reasons, recently recognized as...

journal_title：Journal of biological regulators and homeostatic agents

authors： Carosi G,Torti C,Palvarini L,Quiros Roldan E

更新日期：1999-07-01 00:00:00

abstract：:Activated T-cells are susceptible to induction of apoptosis or programmed cell death in response to ligation of several cell surface structures, including CD2, CD3, and CD95/Fas. These mechanisms may be important in the regulation of immune responses and in prevention of autoimmunity. We used flow cytometric quantitat...

journal_title：Journal of biological regulators and homeostatic agents

authors： Kirsch AH,Mahmood AA,Endres J,Bohra L,Bonish B,Weber K,Fox DA

更新日期：1999-04-01 00:00:00

abstract：:The selection of a kidney graft recipient should be made not only taking into account biological and clinical parameters, for assuring the maximum possible clinical success; the ethical objective to allow every patient equal opportunity of receiving a transplant should also be pursued. In every waiting list of transpl...

journal_title：Journal of biological regulators and homeostatic agents

authors： Curtoni ES,Magistroni P,Fasano ME,Praticò L,Roggero S

更新日期：1999-01-01 00:00:00

abstract：:Various hematopoietic malignant disorders have been shown to bear chromosome abnormalities of the 11q23 band, which can be rearranged with many different chromosomal regions in a wide variety of different leukemia subtypes. Several laboratories have identified a trithorax-related gene that is involved in most of the 1...

journal_title：Journal of biological regulators and homeostatic agents

authors： Gregorini A,Cinti C,Young BD

更新日期：1998-10-01 00:00:00

abstract：:The lack of distinguishing characteristics between lymphoid blastic crisis (BC) of Philadelphia (Ph)+ chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) remains an exciting dilemma. Indeed, the genetic defect of approximately half of Ph+ ALL patients is identical to that identified in CML. Here ...

journal_title：Journal of biological regulators and homeostatic agents

authors： Gregorini A,Filippetti A,Luchetti F,Walker A,Lillington DM,Papa S,Valentini M

更新日期：1997-07-01 00:00:00

abstract：:To investigate the role played by chemokines in the natural history of human immunodeficiency virus (HIV) infection, we measured the plasma levels of RANTES. MIP-1 alpha and MIP-1 beta in a cohort of patients with primary HIV-1 infection (PHI) followed longitudinally. The cohort included 17 patients with well-document...

journal_title：Journal of biological regulators and homeostatic agents

authors： Malnati MS,Tambussi G,Clerici E,Polo S,Algeri M,Nardese V,Furci L,Lazzarin A,Lusso P

更新日期：1997-01-01 00:00:00

abstract：:Conditioned medium from a T-lymphoblastic cell line (Mo) is known to produce factors promoting CFU-GM, BFU-E and CFU-MK. In our study we investigated the potential CSA of conditioned media obtained from Mo and its subclone J on normal and malignant lymphoid progenitors of both T and B lineage. Both cell lines release ...

journal_title：Journal of biological regulators and homeostatic agents

authors： Legitimo A,Consolini R,Bason C,Balleari E,Macchia P

更新日期：1995-10-01 00:00:00

abstract：:Heat-induced total body hyperthermia has been shown to synergistically enhance the in vivo antitumor effects of MuIFN-gamma directed against B16 melanoma in mice. This observation was made with an 8-hour exposure to hyperthermia that was administered following MuIFN-gamma treatment. It was not known whether this was t...

journal_title：Journal of biological regulators and homeostatic agents

authors： Fleischmann WR Jr,Fleischmann CM

更新日期：1994-10-01 00:00:00

abstract：:This study shows that the human hepatoblastoma cell line Hep G2 constitutively expressed a high level of Leukemia Inhibitory Factor (LIF) mRNA in the characteristic major 3.8 and minor 1.8 Kb forms. DNA analysis of the LIF gene from Hep G2 revealed no rearrangements. Production and secretion of significant concentrati...

journal_title：Journal of biological regulators and homeostatic agents

authors： Mezzasoma L,Biondi R,Benedetti C,Floridi C,Ciurnelli R,Falcinelli F,Onorato M,Scaringi L,Marconi P,Rossi R

更新日期：1993-10-01 00:00:00

abstract：:The transcription of HPV-16 E6/E7 RNA has been studied by the polymerase chain reaction (PCR) in the Siha cervical carcinoma cell line. With this technique, all three different transcripts have been detected: the cDNA colinear E6 form, and the two differentially spliced forms E6*I and E6*II. All types of RNA appear le...

journal_title：Journal of biological regulators and homeostatic agents

authors： De Marco F,Marcante ML

更新日期：1993-01-01 00:00:00

abstract：:Pure recombinant human IL-6 inhibits growth of T47D, MCF-7 and SK-BR-3 human breast carcinoma and OVCAR-3 ovarian carcinoma cells in cultures. Subcloning of the breast ductal carcinoma T47D cells yields clones with high and low sensitivity to the growth inhibitory effect of IL-6. The subclones vary 40 fold in their se...

journal_title：Journal of biological regulators and homeostatic agents

authors： Chen L,Shulman LM,Revel M

更新日期：1991-10-01 00:00:00

abstract：:T cell subsets in the synovial fluid (SF) and peripheral blood (PB) of RA patients and controls suffering from different forms of chronic synovitis have been investigated. The immunological evaluation showed a reduction of CD4 subsets in RA-SF compared to RA-PB (p less than 0.001), and an almost complete absence of th...

journal_title：Journal of biological regulators and homeostatic agents

authors： Afeltra A,Galeazzi M,Basso P,Pietrucci A,De Pità O,Ferri GM,Porzio F,Bonomo L

更新日期：1991-04-01 00:00:00

abstract：:It is uncertain whether interferon levels in the interstitial fluid of tumors are equivalent to interferon plasma levels and we have investigated this problem in human pulmonary tumors by infusing human recombinant interferon alpha A and natural interferon Beta for about three hours before surgery. By determining the ...

journal_title：Journal of biological regulators and homeostatic agents

authors： Bocci V,Carraro F,Naldini A,Borrelli E,Biagi G,Gotti G,Giomarelli PP

更新日期：1990-10-01 00:00:00

abstract：:The binding of nuclear proteins from human tumor cells to synthetic double stranded oligonucleotides mimicking upstream regions of the HLA-DR alpha gene was studied. As the HLA-DR alpha gene is inducible by interferon(IFN)-gamma, nuclear extracts were also purified from IFN-gamma treated cells. Our data indicate that ...

journal_title：Journal of biological regulators and homeostatic agents

authors： Gambari R,Barbieri R,Nastruzzi C,Feriotto G,Piva R,Natali PG,Giacomini P

更新日期：1990-07-01 00:00:00

abstract：:The acute effects of interferon alpha-2a (3 x 10 IU im) on catecholamine and immunoreactive beta endorphin plasma levels, cortisol serum levels and lymphocyte beta 2-adrenoceptor density were evaluated in ten healthy volunteers. Interferon induced a significant increase in plasma norepinephrine; there was an increased...

journal_title：Journal of biological regulators and homeostatic agents

authors： Pende A,Musso NR,Vergassola C,Puppo F,Ioverno A,Criscuolo D,Indiveri F,Lotti G

更新日期：1990-04-01 00:00:00

abstract：:Both mouse interferon-beta (MuIFN-beta) and the inhibitor of ornithine decarboxylase (ODC), alpha-difluoromethyl ornithine (DFMO), inhibited the differentiation of mouse 3T3-L1 fibroblasts into adipocytes in a dose-dependent manner. DFMO and MuIFN-beta added together to cultures that were induced to differentiate prod...

journal_title：Journal of biological regulators and homeostatic agents

authors： Taylor JL,Turo KA,McCann PP,Grossberg SE

更新日期：1988-01-01 00:00:00

abstract：:Effects of recombinant human interferon alpha (HuIFN-alpha) on human megakaryocyte (CFU-MK) and fibroblast (CFU-F) colony-forming cell growth were studied. Concentration-dependent inhibition of both CFU-MK and CFU-F by HuIFN-alpha was demonstrated. Statistically significant suppression of both CFU-MK and CFU-F was see...

journal_title：Journal of biological regulators and homeostatic agents

authors： Han ZC,Briere J,Abgrall JF,Le Gall G,Parent D,Sencebe L

更新日期：1987-10-01 00:00:00

abstract：:In an effort to define immunobiological parameters identifying "responders" vs "non-responders" to IFN among hepatitis patients, 16 patients with chronic active hepatitis were screened for changes of Natural Killer cell activity (NK). 10/16 patients replicated the hepatitis B virus (HBV-DNA positive) whereas 6/16 repl...

journal_title：Journal of biological regulators and homeostatic agents

authors： Actis GC,Maran E,Bonino F,Saracco G,Rosina F,Brunetto MR,Baldi M,Rizzetto M,Verme G,Rocca B

更新日期：1987-01-01 00:00:00